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Mage-tarm! Tre metoder Konkurransen er klar over, men det gjør du ikke

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Denne artikkelen gjennomgår den nåværende kunnskapen om virkningen av fiber og prebiotisk forbruk på sammensetningen og metabolsk funksjon av den menneskelige gastrointestinale mikrobiotaen, inkludert effekten av fysiokjemiske egenskaper til komplekse karbohydrater, tilstrekkelig inntak og behandlingsdoser, og de fenotypiske responsene knyttet til sammensetningen. av den menneskelige mikrobiotaen. Noen kostfibre kan også klassifiseres som prebiotiske.9 Prebiotika er definert som "selektivt fermenterte ingredienser som resulterer i spesifikke endringer, i sammensetningen og/eller aktiviteten til den gastrointestinale mikrobiotaen, og dermed gir fordel(er) på vertshelsen."10 Dette gjennomgang diskuterer virkningen av forbruk av kostfiber og prebiotika på den gastrointestinale mikrobiotaen, inkludert rollen til ingrediensenes fysiokjemiske egenskaper og dose, samt de fenotypiske responsene knyttet til sammensetningen av den bosatte mikrobiotaen. Den gastrointestinale mikrobiotaen har en viktig rolle i menneskers helse, og det er økende interesse for å bruke dietttilnærminger for å modulere sammensetningen og metabolske funksjonen til de mikrobielle samfunnene som koloniserer mage-tarmkanalen for å forbedre helsen, og forebygge eller behandle sykdom. Den menneskelige gastrointestinale mikrobiotaen - et av de tettest befolkede mikrobielle samfunnene på jorden - inneholder svært forskjellige mikrobielle samfunn som gir metabolske, immunologiske og beskyttende funksjoner som spiller en avgjørende rolle for menneskers helse.1-3 Den gastrointestinale mikrobiotaen påvirkes av en rekke av faktorer inkludert genetikk, vertsfysiologi (vertens alder, sykdom, stress osv.) og miljøfaktorer som levekår og bruk av medisiner.3-7 I økende grad anerkjennes kosthold som en sentral miljøfaktor som medierer sammensetningen og metabolsk funksjon av gastrointestinal mikrobiota. 8 Faktisk er inntak av spesifikke kostholdsingredienser, som fiber og prebiotika, en vei som mikrobiotaen kan moduleres på.

For eksempel har butyratproduserende bakterier, som Faecalibacterium prausnitzii, og Akkermansia muciniphila, en mucin-nedbrytende bakterie, begge vært assosiert med gunstige helseeffekter, inkludert redusert betennelse og forbedret tarmbarrierefunksjon, henholdsvis.47 Som vår forståelse av rollen til mikrobiotaen i vertshelsen fortsetter å utvide seg, det er sannsynlig at denne definisjonen vil fortsette å utvikle seg. De fysisk-kjemiske egenskapene til fibre inkluderer fermenterbarhet, løselighet og viskositet, og disse egenskapene påvirker ikke bare fermentering, men også de terapeutiske effektene av forbruk. 27 Uløselige fibre, som cellulose, er generelt dårlig gjæret av tarmmikrober, men deres tilstedeværelse i kostholdet øker tarmens transitthastighet og reduserer dermed tiden tilgjengelig for bakteriell tykktarmsgjæring av ikke-fordøyd mat.31 Psyllium er også en ikke-fordøyd matvare. -fermenterbar fiber; dens høye løselighet og viskositet resulterer imidlertid i unike terapeutiske effekter, inkludert forbedret glykemisk kontroll og reduserte kolesterolnivåer i blodet.27,32 Fibre som er svært fermenterbare samtidig som de har høy løselighet og viskositet inkluderer β-glukan og pektiner.27 Disse fibrene finnes naturlig. i kostholdet i fullkorn som havre og bygg (β-glukan) og frukt som epler (pektin).26,28 Senket glukoseabsorpsjon og binding av gallesyrer - mekanismene som ligger til grunn for de fysiologiske fordelene til psyllium, β-glukaner, rabeprazole nettapotek kjøpe og pektin - er også påstått å påvirke den gastrointestinale mikrobiotaen.

Kostfibre er heterogene, mesalamine 400mg på nett og derfor brukes ulike klassifikasjoner for å beskrive dem, inkludert opprinnelse, kjemisk sammensetning og fysisk-kjemiske egenskaper med ytterligere underkategorisering basert på graden av polymerisering (f.eks. kjedelengde). Det er viktig at hver av disse egenskapene også kan påvirke mikrobiell gjæring. Løselige fibre, som kortkjedede fruktooligosakkaider (FOS) og pektin, metaboliseres av bakterier mer proksimalt i mage-tarmkanalen (f.eks. ileam og ascendensende tykktarm), mens fibre som er mindre løselige, som cellulose, kan delvis fermenteres i distal kolon hvor transitttiden er langsommere, og bakterietetthetene er høyere. 42 Nylig ble det vist at fibre med varierende kjedelengde og løselighet forskjellig påvirker sammensetningen av cecal-mikrobiotaen til mus-dietter supplert med 5-10 % cellulose, en uløselig fiber, hadde signifikant forskjellige mikrobielle fellesskapssammensetninger enn mus som konsumerte 10 % FOS eller inulin, løselige fibre.43 Virkningen av fermenterbare fibre i kostholdet, eller mikrobiota-vurderingsbare karbohydrater (MACs),20 har blitt grundig studert. En diettstrategi for å modulere mikrobiotaen er inntak av kostfiber og prebiotika som kan metaboliseres av mikrober i mage-tarmkanalen. I stedet metaboliseres disse polysakkaridene av mikrober som genererer kortkjedede fettsyrer (SCFA), inkludert acetat, propionat og butyrat.

Den mikrobielle omdannelsen av komplekse polysakkarider til monosakkarider involverer forskjellige biokjemiske veier, som formidles av de enzymatiske aktivitetene til mikrober. Generelt er det slik at jo mer komplekst polysakkaridet er, desto mer glykosidase er nødvendig for å metabolisere det.50 Noen bakterier har mange forskjellige enzymer som lar dem metabolisere dusinvis av forskjellige komplekse karbohydrater, mens andre mikrober bare er i stand til å utnytte ett eller noen få forskjellige polysakkarider.. De viktigste bakterielle fermentative sluttproduktene av komplekse karbohydrater er SCFA, nemlig acetat, propionat og butyrat, og gasser (H2 og CO2). I tillegg til graden av polymerisering, påvirker løseligheten av komplekse karbohydrater stedet for gjæring i den menneskelige mage-tarmkanalen. Det som ikke absorberes, fortsetter å bevege seg gjennom mage-tarmkanalen til du blir kvitt det ved å bruke badet. Alliansen din ville selvfølgelig ikke vært omfattende uten felles feiringer når du oppfyller dine ønskede mål. Hvis det ser ut som om du har stoppet opp i vektreduksjonen din og ikke klarer å kvitte deg med de siste kiloene, må du forbedre kraften til treningen du gjør.

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